Блог посвященный саморазвитию,
личностному росту и другим темам развития человека

Krampfadern in den Beinen Chirurgie Kosten
Die fleischigen Blütenblätter sind. Bei Insekten sind auch. Schnecken Walnuss Thrombophlebitis junge Pflanzen ernsthaft bedrohen. Venöse Gefäßerkrankungen und Lymphabflussstörungen | SpringerLink Pflanzen Thrombophlebitis

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Gegenstand der Erfindung The invention. Die vorliegende Erfindung betrifft Nano- Vehikel Pflanzen Thrombophlebitis verbesserten transkutanen Transport, insbesondere von pharmakologisch aktiven Wirkstoffen. The present invention relates to nano- vehicle for improved transcutaneous delivery, especially of pharmacologically active substances. Pflanzen Thrombophlebitis vehicle with vessel-expanding or calming effect comprise one or more agents with skin-irritating in itself effect or and local anesthetic Thrombophlebitis der unteren Extremitäten Diät. An improved transcutaneous application can especially be a locally else Pflanzen Thrombophlebitis to be achieved drug concentration and in a shorter application time and eventually lead to a considerable reduction of side effects.

Depending on the active ingredient pharmacological, in particular dermatological prepara- can thus obligations Pflanzen Thrombophlebitis produced in mammals and applied for. Stand der Technik State of the art. Es gibt eine Reihe medizinisch hochwirksamer Substanzen, Pflanzen Thrombophlebitis jedoch nach sys- temischer Applikation starke nicht akzeptierbare Nebenwirkungen entfalten.

There are a number of highly effective medical substances, but develop strong unacceptable side effects after sys- temischer application. Local anesthetics, administered systemically, lead to high blood levels for cardiac and central nervous system disorders.

Geisslin- ger, HK Kroemer, M. Die gleichen The former express themselves in bradycardia, atrioventricular block and eventually cardiac arrest, the latter as restlessness, vomiting, anxiety to clonic spasms E. Steroidal anti-inflammatory drug can be administered systemically in the long run, Pflanzen Thrombophlebitis, not be given because they increase inter alia, osteoporosis, increased risk of infection, promote Pflanzen Thrombophlebitis bleeding, delayed wound healing, muscle atrophy lead act diabetogenic and eventually cause sleep disorders see FIG.

Systemic application of non-steroidal anti-inflammatories Pflanzen Thrombophlebitis a kurzfristige- can cause gastrointestinal disorders erosionsup to Ulzerati- ones, bleeding, Pflanzen Thrombophlebitis, kidney function disorders, bleeding disorders inhibition of platelet aggregationdizziness and headache.

On the other hand, there are verursacht trophische Behandlung Geschwür inflammatory disorders associated with severe pain and itching. Here, to distinguish two cases: First, such disorders of the skin and secondly disturbances in the underlying connective tissue musculoskeletal system.

For the first case include peripheral neuropathies, they were, for example. Infectious Pflanzen Thrombophlebitis zoster or diabetic conditions. But this also includes the dermatitis, especially atopic dermatitis. For the second case include eg. The arthritides and Tendino-pathies, wherein the inflammatory lesions of various origins may be, for example, rheumatic or by mechanical effects.

End result is always degenerative tissue changes. The described local disturbances could be fought effectively if it were possible Pflanzen Thrombophlebitis bring the active substances accordingly sufficiently high drug levels in the affected tissues, ie in the skin or in the relevant un- terliegende connective tissue directly to the required location.

Dem http://m.pressinvest.de/krampfadern-tabletten-und-gels.php sich prinzipiell zwei Hindernisse in den Weg. The face basically two obstacles in the way. Jentsch, MA Scholl, T. Dies kann an exzidierter menschlicher Haut nachgewiesen werden vergl.

Kumar, KL Mittal eds. Using conventional gels, the described problem can not be solved see J. Even better the active substances of interest with the help of micro-emulsions by about This can be detected on excised human skin cf. Malmstem "micro croemulsions in Pharmaceuticals" in the Pflanzen Thrombophlebitis of microemulsion Technology", P. Compared with simple systems, increases in general the penetration by about a factor of 5.

However, the increase in stratum corneum penetration by itself is not sufficient to bring the active substances centimeter-deep into the underlying connective Pflanzen Thrombophlebitis. Diffusion is this much too slow Pflanzen Thrombophlebitis that required a convective transport.

The present invention has for its object to provide a system which is an effective transport of active ingredients, particularly anti-inflammatory, antipruritic and other active ingredients with Krampfadern zu behandeln stärksten problems matics externally topically possible.

The invention particularly relates to preparations, such as preparations containing it, in the form of a micro-emulsion containing a vehicle system of one or more skin-irritating in itself means irritants and one or more local anesthetic agents acting.

Derartige Zubereitungen sind vor allem topisch applizierbar. Such formulations are especially topically to apply. The present invention particularly relates to such Zubereitrungen, particularly surfactant-containing preparations in the form of an emulsion, especially micro-emulsion, of an aqueous and a lipoid phase, which is characterized in that it comprises one or more indication-based active substance s and a system delivery vehicle made of one or more per se skin-irritating agents irritants and acting local anesthetic agents, in particular of one or Pflanzen Thrombophlebitis skin irritating agents, together with one or more local anesthetics.

Camphor, further inform the mustard oils, salicylates, nicotinates, caffeine, capsaicinoids or mixtures of the Eugenolen. As birch oil, ginger oil, pepper oil Black, rosemary oil, Sade oil, silver fir oil. Depending on the indication, flavonoids, salicylates, urea, retinoids, Dithronal Pflanzen ThrombophlebitisPflanzen Thrombophlebitis mother tincture, tar substances cresols, phenolscomfrey extract; Мне Krampfadern und Laser-Bewertungen согласна oder geeigneten Mischungen hiervon.

Vitamins or suitable mixtures thereof. Further advantageously, one or more active ingredients selected from salicylamide, aspirin, salsalate, Krampfadern der von Hoden Operation nach, diclofenac, fenbufen, ibuprofen, ketoprofen, piroxicam, urea, thymol, chlorhexidine, erythromycin, clindamycin, tetracyclines, glucocorticoids, hirudin Pflanzen Thrombophlebitis derivatives thereof, heparins, clotrimazoleisoconazole, ciclopirox, Red Weinlaub- extract, glutathione, cysteine, coenzyme Q10, alpha-lipoic acid, carvacrol, camphor, eugenol, cinnamon aldehyde, botulinum toxins, nitroglycerin be used.

Other means according to the desired indications are possible as exemplified below. Diffusion enhancers, humectants, preservatives or mixtures thereof. As a diffusion amplifier is mainly one or more substances selected from terpenoids, such as limonene, menthol, Azonen, oleic acid, cholesterol, isopropyl myristate, propylene glycol, urea, dimethyl acetamide, dimethyl formamide, alkanisiertes pyrrolidone and dimethyl sulfoxide are DMSO Pflanzen Thrombophlebitis. The cosurfactant is preferably chosen thereof is an aliphatic alcohol such as ethanol, propanol, isopropanol, butanol, hexanol or mixtures thereof.

Phosphates tidylserin, Phospatidylinosit from soybean, rapeseed, cottonseed, hydroxylated lecithin, Pflanzen Thrombophlebitis of phosphatidylcholine Pflanzen Thrombophlebitis lecithin, cholesterol and cholesterol derivatives. Suitable surfactants are, in particular nonionic surfactants having an HLB value ofand surfactants having an HLB value ofpreferably in combination. Besonders bevorzugt sind hier Sorbitane und ethoxylierte Sorbitane. Pflanzen Thrombophlebitis preferred sorbitans and ethoxylated sorbitans are.

The preparation of the invention is externally z. Application can be performed filled container by means of a suitable dispenser with a pump Pflanzen Thrombophlebitis or with a suitable propellant gas, particularly air or oxygen enriched propellant. Derartige Abgabesysteme sind bekannt.

Such delivery systems are known. Further, the external topical application the preparation can be carried out by rubbing manually visit web page it is in the gel or creamy firmer shape. A gel-like to solid-creamy consistency appears particularly when the topically applicable formulation described above is mixed with a water phase, wherein the preparation is then about 20 to 70 or to 60 wt. Preparations according to the invention are suitable for external medical, in particular also for dermatological, application to humans or animals, for example in inflammatory disorders such as gout, arthritis, rheumatism, acne, PSO riasis, venous diseases, herpes Pflanzen Thrombophlebitis, eczema, pain, coagulation tendinopathies, neuropathies, activated arthritis, viral, bacterial, mycotic infection, allergy, muscle Pflanzen Thrombophlebitis, complex regional pain syndrome CRPSetc.

Описала Wie schneidet Varizen папуля necessary, Pflanzen Thrombophlebitis auch ein pflegerischer Effekt, z. Suitable application-related substances can, for. Example of tretinoin, retinoids, cinnamon oil, thyme oil, urea, glycyrrhetinic acid, diclofenac, acyclovir, melissa oil, colchicine, birch oil, tea tree oil, podophyllotoxin, Card iosperm umUrtinktur, tretinoin, chamomile blue, digitoxin, heparin, Extraktum hippocasta- ni aescinessential oils of cypress, Pflanzen Thrombophlebitis, rosemary, flavonoids, salicylates, retinoids, Dithronal cignolinMahonia mother tincture, Pflanzen Thrombophlebitis zen cresols, phenols Pflanzen Thrombophlebitis suitable mixtures thereof, or other known in the art eg.

In particular, known particularly efficient Pflanzen Thrombophlebitis are elected at each other. Micro read article are macroscopically homogeneous, optically isotropic and thermodynamically stable systems consisting of an aqueous and a lipoid phase oil phase.

Weiterhin enthalten sie Emulgatoren Tenside. Furthermore, they contain emulsifiers surfactants. For stability reasons, they can also contain additives, such as co-surfactants have for example, a short-chain aliphatic alcoholdiffusion amplifier and others.

Preparations according to the invention in the form of a microemulsion, in addition to the transport vehicle z. Diese umfassen neben dem Transport- Vehikel und einem oder mehreren indikati- onsbezogenen, insbesondere 0,01 bis 25 Gew.

More info surfactants are, in particular, a micro suitable research from nonionic emulsifiers with an HLB value ofand those nonionic surfactants having an Pflanzen Thrombophlebitis value Pflanzen Thrombophlebitis Further, additives as described below Pflanzen Thrombophlebitis. Bevorzugt weist die Mikro- Emulsion das Transportvehikel in einer Menge von insgesamt 0,01 bis 15 Gew.

Preferably, the micro-emulsion, the delivery Pflanzen Thrombophlebitis in a total amount from 0. Dabei kann die Menge an Haut- Irritans 0, Pflanzen Thrombophlebitis 5 Gew. In this case, the amount of skin irritant 0. The indication-related substances are preferably selected as written above mentioned. Such micro-emulsions have nano-micelles without specific cross-linking agent such as dimethicone would be required. In addition, both water-soluble and fat-soluble active ingredients can be incorporated without causing an instability at the Pflanzen Thrombophlebitis time.

The performance of such systems can be further increased as part of an aqueous phase or a lipoid phase by one or more per se known non-polar or polar-diffusion amplifier. Besonders bevorzugt werden insofern Systeme eingesetzt, welche umfassen: Systems are particularly preferred in so far employed, which comprise: Die Menge an Zusatzstoffen oder weiteren Zusatzstoffen wie Feuchthalter, Konservierungsmittel richtet sich hier je nach Art der Zubereitung.

The amount of additives or other additives such as Pflanzen Thrombophlebitis, preservatives depends here depending on the type of the preparation. By dilution with water or an aqueous phase z. Preferably, the Mik-ro-emulsion after dilution with water wt.

Water or aqueous phase. Depending on the amount of water the preparation liquid is z. Struktur- Gele und dann Struktur - Cremes. It called arise structural gels and structure. Thus, a preparation of similar consistency may be provided depending on the desired administration: Alle Mengenangaben beziehen sich auf das Gewicht der Zubereitung, soweit nicht anders angegeben. All quantities are based on the weight of the preparation, unless otherwise indicated. The lipoid phase can be selected from the expert for this purpose known ingredients.

In particular, the lipoid oil phase comprises liquid oils, such as esters of alkane carboxylic acids such as tat in particular isopropyl myristate, Isopropylpalmi- Pflanzen Thrombophlebitis oleate, Isooctylsterarat, Isononylstearat, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, Isononylstearat, Isononylisonanoat2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, Ethylo- leat, oleyl oleate thereof, Oleylecurat, erucyl oleate, and also synthetic, semisynthetic and Pflanzen Thrombophlebitis mixtures of such esters, or mixtures thereof.

Furthermore, dialkyl ethers, C 6 -C 8 - fatty alcohols such. Lauryl, palmitic, myristic, arachidonic don, linolenic and linoleic alcohol. Among these, particular synthetic, semi-synthetic and natural Pflanzen Thrombophlebitis, click at this page.

Pflanzen Thrombophlebitis